Paul Verhoeff, MD, PhD, FRCPC
Associate Professor of Psychiatry Department of Psychiatry, Geriatric Program, University of Toronto
Staff Psychiatrist Brain Health Centre, Behavioural Neurology Memory Disorders Clinic, and Geriatric Psychiatry Community Service, Baycrest Centre for Geriatric Care
Neuropsychiatry Clinician-Scientist and Staff Psychiatrist Kunin-Lunenfeld Applied Research Unit, Geriatric Psychiatry Community Service, Baycrest Centre for Geriatric Care
- Cerebral β-Amyloid imaging with PET in patients with Alzheimer’s disease (2001-present) and with SPECT in patients with amyloid angiopathy (1991-1996).
- Neostriatal dopamine D2 receptor imaging with PET in patients with schizophrenia and in healthy subjects before and after catecholamine depletion with α-methyl-para-tyrosine (1999-2001), in patients with schizophrenia off and on antipsychotics (1999-2004), and in patients with major depressive disorder (2001-2004), bipolar disorder (1997-2000); with SPECT in patients with Tourette disorder (1990-1994), partial epilepsy (1991-1994), Parkinsonian syndromes (1990-1993), pituitary macroadenomas (1990-1993), migraine (1990-1993), HIV encephalopathy (1990-1991), in patients with schizophrenia off and on antipsychotics (1990-1995), in healthy subjects (1990-1993), and in MPTP-treated and control nonhuman primates (1990-1994); with a planar gamma-camera for dosimetry in healthy subjects (1990-1993); ex vivo in rodents (1988-1991); and in vitro in humans and rodent brain tissues (1988-1991).
- Extrastriatal dopamine D2 receptor imaging with SPECT in healthy subjects (1997-2000).
- Neostriatal dopamine D1 receptor imaging with PET in healthy subjects before and after catecholamine depletion with α-methyl-para-tyrosine (1999-2001); and with SPECT in healthy subjects (1991-1993).
- Cerebral serotonin 5-HT1A receptor imaging with PET in patients with Alzheimer’s disease (2001-present), frontotemporal dementia (2001-present), and schizophrenia (1999-2003), and in healthy subjects (1999-2001).
- Cerebral serotonin 5-HT2A receptor imaging with PET in patients with schizophrenia (1999-2000).
- Cerebral GABAA-benzodiazepine receptor imaging with SPECT in patients with alcohol dependence (1997-2004), post-traumatic stresss disorder (1997-2004), major depressive disorder (1997-2003), schizophrenia (1994-1999), epilepsy (1994-1999), and in healthy subjects off and on benzodiazepines (1988-1999).
- Cerebral muscarinic acetylcholinergic mACh receptor imaging with SPECT ex vivo in rats (1988-1993).
- Pituitary somatostatin receptor imaging with SPECT in patients with pituitary adenomas and in healthy subjects (1992-1996).
- Cerebral blood flow imaging with SPECT in patients with Alzheimer’s disease (1988-1992), partial epilepsy (1988-1992), and ischemic stroke (1988-2001).
- Physiological measurements of early and late asthmatic responses to submaximal exercise challenge before and after nedocromil sodium in patients with intrinsic and extrinsic bronchial asthma (1988-1990).
Research Focus
Most of my research activities have centered around neuroreceptor imaging in vivo with positron emission tomography (PET) or single-photon computerized tomography (SPECT) in patients with neuropsychiatric disorders and in healthy control subjects. The research projects are listed according to the neurochemical transmission systems that have been studied, with further clarification as to which patient groups were involved during which period:Publications
Education
- 2003: Diplomate of the American Board of Psychiatry and Neurology, Inc., Member Board of the American Board of Medical Specialties, (# 53130 )
- 2003: Examination Part II, American Board of Psychiatry and Neurology
- 2002: Certificate of Registration for Independent, Practice from the College of Physicians and Surgeons of Ontario (# 74459)
- 2001: Licentiate of the Medical Council of Canada, Canadian Medical Register (# 91136 )
- 2001: Qualifying Examination Part II , Medical Council of Canada (# 9980517)
Academic Appointments
- 2005–Present: Associate Professor of Psychiatry, Department of Psychiatry, Geriatric Program, University of Toronto, Toronto, Ontario, Canada (# 1016849 )
- 2003–Present: Staff Psychiatrist, Brain Health Centre, Behavioural Neurology Memory Disorders Clinic, and Geriatric Psychiatry Community Service, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
- 2001–Present: Neuropsychiatry Clinician-Scientist and Staff Psychiatrist, Kunin-Lunenfeld Applied Research Unit, Geriatric Psychiatry Community Service, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Reviewership
Consulting
- 1992: European Journal of Nuclear Medicine
- 1999: Psychopharmacology
- 2001: American Journal of Psychiatry
- 2001: Journal of Neurochemistry
- 2000–2001: Journal of Neuropsychiatry and Clinical Neurosciences
- 2003: Journal of Neuropsychiatry and Clinical Neurosciences
- 2001–2003: Journal of Psychiatry and Neuroscience
- 2002: NeuroImage
- 2002: Archives of General Psychiatry
- 2003–2010: American Journal of Geriatric Psychiatry
- 2005: American Journal of Geriatric Psychiatry
- 2000: Neuropsychopharmacology
- 2000–2003: Psychiatry Research: Neuroimaging
- 2003: Biological Psychiatry
- 2004: Brain
Committee
- 2010: Thesis (Dr. Christina Siwak, PhD (2002). Thesis: Age-related changes in non-cognitive behaviours in a canine model of aging and dementia and therapeutic evaluation of adrafinil and modafinil. )
- 2010: Thesis (Ms. Jennifer Glass, MSc (2002-present). Thesis: Clinical effects of benzodiazepines in the elderly. )
- 2010: Thesis (Ms. Pearl Behl, MSc (2004-present). Thesis: Longitudinal effects of cholinergic therapy on Alzheimer’s disease (AD)- a neurobehavioral, structural and functional imaging study. )
- 2010: Thesis (Matthew Parrott (2005-present). Thesis: Postprandial memory response in MCI/MCI-like subjects.)
- 2010: European Association of Nuclear Medicine Neuroimaging Committee (Professional Committee )
- 2004: National Institutes of Health – National Institute of Aging Review Committee member (Professional Committee: "reverse" site visit from July 29-30, 2004, in Bethesda, MD, USA, to review a Program Project Grant application by the University of Pittsburgh School of Medicine on behalf of Dr. Steven DeKosky, MD, PhD: "In Vivo PIB PET Amyloid Imaging: Normals, MCI & Dementia." )
- 2004: National Institutes of Health – National Institute of Aging Review Committee member (Professional Committee: "reverse" site visit from November 2-3, 2004, in Bethesda, MD, USA, to review a Program Project Grant application by the University College of Los Angeles on behalf of Dr. Gary Small, MD: "Amyloid Imaging in Aging.")
Membership
- 2010: American Psychiatric Association (Member # 80011 )
- 2010: Canadian Medical Association (Member # 120718)
- 2010: Ontario Medical Association (Member # 079-4834)
- 2010: Canadian Medical Protective Association (Member # 1001169)
- 2010: Scientific Review Board of the Institute for the Study of Aging
Distinctions and Awards
- 2005: Outstanding Service Award, Baycrest Centre for Geriatric Care, Employee Recognition and Rewards Committee Implementation Team at Baycrest Centre for clinical services provided at the Brain Health Centre Memory Disorders Clinic, April 29, 2005 , 75.00
- 2004: Alzheimer’s Association Travel Fellowship 2004, 9th International Conference on Alzheimer's Disease and Related Disorders, USD. July 17-22, 2004, Philadelphia, Pennsylvania, USA, 645
- 2003: International Junior Investigator Award 2003, International College of Geriatric Psychoneuropharmacology (ICGP) , USD. Provided at the International College of Geriatric Psychoneuropharmacology 3rd Annual Meeting, December 12-14, 2003 San Juan, Puerto Rico. , 2,000
- 1999: American Psychiatric Association/Lilly Resident Research Award 1998-1999, American Psychiatric Association annual meeting, USD. Washington, DC , 1,500
- 1998: American College of Neuropsychopharmacology (ACNP) Travel Award 1998, Bristol-Myers-Squibb and the American College of Neuropsychopharmacology 37th annual meeting, USD. Las Croabas, Puerto Rico , 2,000
- 1990: Mallinckrodt-Award 1990 - best presentation from the Benelux, Congress of the European Association of Nuclear Medicine in Amsterdam, Hfl (Dutch guilders), 2,500
Research Projects
External
-
2004–2006:
β-amyloid PET imaging in Alzheimer’s disease
Sponsors: Alzheimer’s Association New Investigator Research Grant, 100,000 (USD)
-
2003–2006:
Beta amyloid PET imaging in vivo for early detection of Alzheimer's disease
Sponsors: Scottish Rite Charitable Foundation of Canada’s Major Research Grant, 104,983 (CAD)
-
2002–2004:
Imaging amyloid plaques with PET in patients with Alzheimer’s disease
Sponsors: Alzheimer Society of Canada Young Investigator Grant, 50,000 (CAD)
Fellow of the Royal College of Physicians and Surgeons of Canada (# 556363)
November 2000:
Passed Royal College of Physicians and Surgeons Psychiatry Examination Part II(# 556363)
September 2000:
Passed Royal College of Physicians and Surgeons Psychiatry Examination Part I(# 556363)
May 2000:
Passed Medical Council of Canada Qualifying Examination Part I (# 9980517)
January 2000:
Certificate of Registration for Postgraduate Education from the College of Physicians and Surgeons of Ontario (# 74459)
October 1999:
Physician Licensure in The Netherlands, European Union (# 29024521601)
September 1999:
Passed Medical Council of Canada Evaluating Examination (# 9980517)
November 1998:
Passed American Board of Psychiatry and Neurology Examination Part I
November 1996:
Physician Licensure in Connecticut, United States of America (# 035708)
February 1996:
Passed United States Medical Licensure Examination Steps 1, 2 and 3 (# 0-505-330-1)
April 1993:
PhD Thesis Neurosciences Amsterdam on theme: Neuroreceptor Imaging with SPECT',
University of Amsterdam (cum laude)
October 1988:
MD by Medical Qualifying Examination (cum laude), Erasmus University Rotterdam
September 1986:
Examination for the 'drs.' degree in Medicine, Erasmus University Rotterdam
July 1983:
Propaedeutics in Medicine (cum laude), Erasmus University Rotterdam
Assistant Professor of Psychiatry (# 1016849)
Department of Psychiatry, Geriatric Program,
University of Toronto, Toronto, Ontario, Canada
August 1999-July 2001
Clinical Research Fellow
Schizophrenia/PET Centre, Clarke Division,
Centre for Addiction and Mental Health,
Toronto, Ontario, Canada
July 1998-July 1999
Advanced Resident and Fellow in Addiction Psychiatry,
Department of Psychiatry,
Yale University School of Medicine, New Haven,
Connecticut, United States of America
July 1994-June 1998
Resident, Department of Psychiatry,
(Neuroscience Research Training Program)
Yale University School of Medicine, New Haven,
Connecticut, United States of America
March 1994-June 1994
Resident, Department of Psychiatry,
Cluster of Patients with Schizophrenia,
Academic Hospital Groningen, Netherlands
March 1993-February 1994
Served as MD and First-Lieutenant,
Dutch Landforces at the Central Section for Individual Psychosocial Aid.
Worked as clinical psychologist.
2. Organized from September 2005 until the present the weekly Grand Rounds at the Baycrest Department of Geriatric Psychiatry.
3. Organized as Course Director the KLARU-Baycrest-CAMH-UofT Division of Geriatric Psychiatry Conference “Behavioural Problems in Dementia - Late-Life Depression: Connecting Research and Clinical Care”, which was held on October 20, 2006.
4. Presenting regularly at the following rounds at Baycrest Centre for Geriatric Care (for specific presentations, see Oral Conference Presentations list below):
a. Baycrest Centre Grand Rounds
b. Evidence Based Clinical Practice Seminars
c. Geriatric Psychiatry Seminar Series
d. Grand Rounds at the Baycrest Department of Geriatric Psychiatry
e. Kunin-Lunenfeld Applied Research Unit Rounds
f. Rotman Research Institute Rounds
g. Rounds at the Department of Behavioural Neurology.
5. Supervisor of psychiatry resident Dr. Eileen Sloan, MD, PhD, from March 20, 2003, until June 30, 2003.
6. Supervisor of geriatric medicine fellow Dr. Tricia Woo, MD, from July 18, 2003, until July 31, 2003.
7. Supervisor of psychiatry resident Dr. Treena Wilkie, MD, from July 8, 2003, until December 31, 2003.
8. Supervisor of clinical research fellow Dr. Shinichiro Takeshita, MD, PhD, and Neurosurgeon in Japan, from October 17, 2003, until October 16, 2005.
9. Supervisor of psychiatry resident Dr. Michele Korostil, MD, from January 5, 2004, until June 30, 2004.
10. Supervisor of psychiatry resident Dr. Jinous Hamidi, MD, from July 1, 2004, until December 31, 2004.
11. Supervisor of psychiatry resident Dr. Virginia Wesson, MD, from January 1, 2005, until June 30, 2005.
12. Supervisor of clinical research fellow Dr. Kie Honjo, MD, PhD, and Neurologist in Japan, from April 1, 2005, until September 30, 2005.
13. Supervisor of the following fellows, residents and medical students at the Baycrest Behavioural Neurology Memory Disorders Clinic:
a. Dr. Philip Lee, MD, FRCPC (behavioural neurology fellow) from December 1, 2003, until February 15, 2004
b. Dr. Yakir Kaufman, MD (behavioural neurology fellow) from December 1, 2003, until June 30, 2004
c. Dr. Laura McCabe, MD (PGY-5 psychiatry resident) from December 1, 2003, until December 31, 2003
d. Dr. Esther Bui, MD (neurology resident) from January 1-31, 2004
e. Dr. Tricia Woo, MD (geriatric medicine fellow) from February 1-28, 2004
f. Dr. Andrew Lim, MD (neurology resident) from July 1, 2004, until August 2, 2004
g. Dr. Yael Friedman, MD (neurology resident) from August 3, 2004, until August 28, 2004
h. Dr. Khalid Hassan, MD(neurology resident) from November 1, 2004, until November 28, 2004
i. Dr. Elizabeth Layne, MD (PGY-5 psychiatry resident) from November 29, 2004, until January 2, 2005
j. Dr. Mihaela Nicula, MD (geriatric medicine fellow) from January 3, 2005, until January 30, 2005.
k. Dr. Nahathai Wongpakaran, MD (geriatric psychiatry fellow from Thailand) from December 2, 2004, until May 31, 2005 (observer status only).
l. Dr. Ling Yap, MD (geriatric psychiatry fellow from Singapore) on April 21, 2005 (observer status only).
m. Dr. Daniel Martinez, MD (geriatric medicine fellow from Argentina) on May 6, 2005 (observer status only).
n. Dr. Marcelo Blacutt, MD (geriatric medicine fellow from Chile) from June 9, 2005, until June 30, 2005.
o. Dr. Vincenzo Santo Basile, MD (neurology resident) from September 1, 2005, until October 2, 2005.
p. Dr. Thirumgalal Yogaparan, MD (geriatric medicine fellow from Sri Lanka and the USA) from November 1, 2005, until December 31, 2005.
q. Dr. Diyana Docheva, MD (geriatric medicine fellow from Bulgaria) on April 11, 2006.
r. Dr. Fabricio Joao Pio, MD, (neurology fellow from Brazil) from April 25, 2006, until May 31, 2006.
s. Dr. Jiwon Oh, MD (neurology resident) from September 12, 2006, until September 26, 2006.
t. Dr. Yael Perez, MD (neurology resident) from October 10, 2006, until October 27, 2006.
u. Dr. Suvendrini Lena, MD (neurology resident) from November 20, 2006, until November 22, 2006.
v. Dr. Phil Gerretsen, MD (4th year medical student from McMaster University, Hamilton, Ontario) from January 9, 2007, until January 19, 2007.
w. Dr. Maria Luisa Pio-Ferreira (4th year medical student from Brazil) on January 16, 2007.
5. National Alliance for Schizophrenia and Affective Disorders Young Investigator Award: from July 1, 1999 – June 30, 2001. Title: Imaging striatal synaptic dopamine levels and dopamine D2 receptor binding potential in schizophrenic patients and in control subjects using [11C]raclopride PET. Total amount: $ 60,000 (US)
6. Ontario Mental Health Foundation Postdoctoral Fellowship: from July 1, 1999 – June 30, 2001. Title: Imaging striatal synaptic dopamine levels and dopamine D2 receptor binding potential in schizophrenic patients and in control subjects using [11C]raclopride PET. Total amount: $ 65,300 (Canadian)
Grant support (Collaborator):
1.
Alzheimer Society of Canada: from September 1, 2006 – August 31, 2008.
Principal investigator: Dr. Angela Troyer, PhD, CPsych. Title: Amnestic
Mild Cognitive Impairment: Cognitive and Neural Mechanisms. Total
amount: $149,977 (Canadian).
2. Orphan Medical Inc.: from
January 1, 2004 - December 31, 2006. Principal Investigator: Dr. Morris
Freedman, MD, FRCPC. Title: Gammahydroxybutyrate in Alzheimer's
Disease: Cognitive, Behavioural and EEG Effects. Total amount: $822,765
(Canadian)
3. CIHR Randomized Controlled Clinical Trials Unit:
from October 1, 2002, until September 30, 2005. Principal Investigator:
Dr. Robert van Reekum, MD, FRCPC. Title: A Randomized Controlled Trial
of the effects of donepezil on cognitive, behavioural, and functional
outcome in traumatic brain injury. Total amount: $ $334,326 (Canadian)
Curriculum Vitae
Download Curriculum Vitae hereContact
Kunin-Lunenfeld Applied Research UnitBaycrest
3560 Bathurst Street, 762
Toronto, Ontario
Canada M6A 2E1 Phone: 416-785-2500-x2167 Email: pverhoeff
klaru-baycrest.on.ca Fax: 416-785-4230
